期刊
BRITISH JOURNAL OF HAEMATOLOGY
卷 117, 期 1, 页码 130-132出版社
BLACKWELL PUBLISHING LTD
DOI: 10.1046/j.1365-2141.2002.03409.x
关键词
relapsed APL; arsenic trioxide; all-trans retinoic acid
类别
The optimal treatment of acute promyelocytic leukaemia (APL) recurring from relapses successfully treated using arsenic trioxide (As2O3 ) is undefined. Three APL patients relapsing from As2O3-induced remission were studied. Re-treatment with As2O3 failed in one patient in third relapse, and resulted in morphological but not molecular remission in another patient. Combination therapy with As2O3 and all-trans retinoic acid (ATRA), however, resulted in morphological and molecular remission in all three cases, with a follow-up time ranging from 6 to 16 months. Our results suggest a synergistic therapeutic effect between As2O3 and ATRA in APL in advanced relapse.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据