期刊
MOLECULAR ECOLOGY
卷 11, 期 4, 页码 771-783出版社
WILEY
DOI: 10.1046/j.1365-294X.2002.01474.x
关键词
computer simulations; F-ST; gene flow; microsatellites; population structure; R-ST
Microsatellite loci mutate at an extremely high rate and are generally thought to evolve through a stepwise mutation model. Several differentiation statistics taking into account the particular mutation scheme of the microsatellite have been proposed. The most commonly used is (R-ST) over cap, which is independent of the mutation rate under a generalized stepwise mutation model. (F-ST) over cap and (R-ST) over cap are commonly reported in the literature, but often differ widely. Here we compare their statistical performances using individual-based simulations of a finite island model. The simulations were run under different levels of gene flow, mutation rates, population number and sizes. In addition to the per locus statistical properties, we compare two ways of combining (R-ST) over cap over loci. Our simulations show that even under a strict stepwise mutation model, no statistic is best overall. All estimators suffer to different extents from large bias and variance. While (R-ST) over cap better reflects population differentiation in populations characterized by very low gene-exchange, (F-ST) over cap gives better estimates in cases of high levels of gene flow. The number of loci sampled (12, 24, or 96) has only a minor effect on the relative performance of the estimators under study. For all estimators there is a striking effect of the number of samples, with the differentiation estimates showing very odd distributions for two samples.
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