期刊
BIOSENSORS & BIOELECTRONICS
卷 17, 期 4, 页码 297-302出版社
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/S0956-5663(01)00298-6
关键词
BioMEMS; monitoring; integration; microfluidics; cross talk free; stability
For simultaneous measurement of glucose, lactate, glutamine, and glutamate a biosensor array is implemented in a micro flow-system thus giving a microsystem. The microsystem consists of a glass chip with the integrated biosensor array and a bottom part, which comprises a gold counter electrode, a 300 m thick seal, and electrical interconnection lines. The flow device has a total internal volume of 2.1 or 6 mul when integrated with a mixer on chip. The biosensors with no crosstalking and high long term stability were produced by modifying the electrochemical transducers and utilizing photopatternable enzyme membranes. The use of appropriate miniaturization technology leads to mass producable devices for in vivo and ex vivo applications in whole blood and fermentation broth. Due to a novel glutaminase with an activity optimum in the neutral pH range direct and simultaneous monitoring of glutamine together with glucose, lactate, and glutamate could be performed. (C) 2002 Elsevier Science B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据