期刊
ANNALS OF BIOMEDICAL ENGINEERING
卷 30, 期 4, 页码 430-446出版社
BIOMEDICAL ENGINEERING SOC AMER INST PHYSICS
DOI: 10.1114/1.1467924
关键词
arterial fluid mechanics; macromolecular transport; atherosclerosis; low density lipoprotein
资金
- NHLBI NIH HHS [R01 HL41372] Funding Source: Medline
The localization of atherosclerotic lesions is due, in part, to regional variations in the permeability of arterial endothelium to macromolecules. In turn, endothelial permeability may be influenced by fluid shear stresses. The spatial variation in endothelial permeability is reviewed and evidence for shear stress dependence upon permeability is presented. These results are examined in light of various signaling mechanisms that increase permeability by increasing the transport of water and macromolecules through the junctions separating endothelial cells. Signaling pathways cause a change in the dense peripheral band of actin and actin stress fibers or alter the phosphorylation of junction proteins which affects their ability to localize in junctions. Future directions to clarify the effect of shear stress on permeability are considered. (C) 2002 Biomedical Engineering Society.
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