期刊
NEUROIMAGE
卷 15, 期 4, 页码 797-809出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1006/nimg.2001.0994
关键词
diffusion tensor imaging; tractography; macaque; anatomical connectivity
资金
- Multiple Sclerosis Society [491] Funding Source: Medline
- Wellcome Trust [077029] Funding Source: Medline
Diffusion tensor imaging (DTI), a magnetic resonance imaging technique, is used to infer major axonal projections in the macaque and human brain. This study investigates the feasibility of using known macaque anatomical connectivity as a gold-standard for the evaluation of DTI tractography methods. Connectivity information is determined from the DTI data using fast marching tractography (FMT), a novel tract-tracing (tractography) method. We show for the first time that it is possible to determine, in an entirely noninvasive manner, anatomical connection pathways and maps of an anatomical connectivity metric in the macaque brain using a standard clinical scanner and that these pathways are consistent with known anatomy. Analogous human anatomical connectivity is also presented for the first time using the FMT method, and the results are compared. The current limitations of the methodology and possibilities available for further studies are discussed. (C) 2002 Elsevier Science (USA).
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