期刊
BIOCHEMICAL SOCIETY TRANSACTIONS
卷 30, 期 -, 页码 201-207出版社
PORTLAND PRESS
DOI: 10.1042/bst0300201
关键词
protease-activated receptor; thrombin; tissue factor; tumour
Tumours are capable of activating blood coagulation through the expression of procoagulant molecules such as tissue factor, cancer procoagulant and hepsin. Initiation of the clotting cascade results in the generation of the activated serine proteases factor VIIa, factor Xa and thrombin. These proteases act via protease-activated receptors and tissue factor to alter gene expression, thereby modulating tumour cell growth, invasion, metastasis and angiogenesis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据