期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 46, 期 4, 页码 1122-1124出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.46.4.1122-1124.2002
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We compared the efficacies of quinupristin-dalfopristin (Q-D; 30 mg/kg of body weight every 8 h) and vancomycin (60 mg/kg twice daily), alone or in combination with rifampin (10 mg/kg twice daily), in a rabbit model of methicillin-resistant Staphylococcus aureus knee prosthesis infection. In contrast to vancomycin, Q-D significantly reduced the mean log(10) CFU per gram of bone versus that for the controls. The combination of rifampin with either Q-D or vancomycin was significantly more effective than monotherapy.
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