期刊
NATURE IMMUNOLOGY
卷 3, 期 4, 页码 399-406出版社
NATURE AMERICA INC
DOI: 10.1038/ni776
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- NIGMS NIH HHS [GM07739] Funding Source: Medline
To examine how B cell receptor affinity affects clonal selection in thymus-independent type 2 (T1-2) immune responses, we produced mice with antibodies that showed a 40-fold difference in affinity for the hapten (4-hydroxy-3-nitrophenyl) acetyl (NP). The difference in the responses of high- and low-affinity B cells to NP-Ficoll was only twofold. However, in competition experiments only the high-affinity B cells responded to antigen. CD19 deficiency increased the affinity threshold of T1-2 responses, whereas Lyn deficiency enhanced clonal expansion but abrogated B cell terminal differentiation. Thus, in T1-2 immune responses, large differences in affinity produce only small differences in the intrinsic ability of B cells to respond to antigen, and selection for high- affinity clones is due to clonal competition during the earliest stages of the response.
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