期刊
BIOINFORMATICS
卷 18, 期 4, 页码 626-630出版社
OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/18.4.626
关键词
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Using a novel algorithm for protein sequence/structure analysis, we propose a probable homology between the SWIB domain (the conserved domain of the 60 kda subunit of the SWIB complex involved in chromatin remodelling) and the p53-binding domain of the MDM2 oncoprotein. The homology suggests that the SWIB domain would adopt a structure similar to that of the MDM2 domain and that these two families of proteins may share a similar functional mechanism. Contact: kenji@cryst.bioc.cam.ac.uk.
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