期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 125, 期 1-2, 页码 59-65出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0165-5728(02)00033-4
关键词
adhesion molecules; cerebral ischemia; fractalkine stroke
Fractalkine (FKN), also known as neurotactin, is a CX3C chemokine that exists in both secreted and neuronal membrane-bound forms and is upregulated during brain inflammation. There is accumulating evidence that FKN induces chemotaxis by binding to its receptor CX(3)CR1 on leukocytes and microglia. We generated FKN-deficient mice to study the role of FKN in postischemic brain injury. After transient focal cerebral ischemia, FKN-deficient mice had a 28% reduction in infarction size and lower mortality rate, when compared to wild-type littermates. The findings of this study indicate a possible role for FKN in augmenting postischemic injury and mortality after transient focal cerebral ischemia. (C) 2002 Elsevier Science B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据