期刊
EUROPEAN JOURNAL OF HAEMATOLOGY
卷 68, 期 4, 页码 217-224出版社
WILEY
DOI: 10.1034/j.1600-0609.2002.01662.x
关键词
immunoglobulin; V-H gene usage; somatic hypermutation; mantle cell lymphoma
类别
Mantle cell lymphoma (MCL) is considered to derive from naive, pregerminal center (GC) CD5(+) B-cells. However, the cell of origin has been questioned in recent studies that showed somatic hypermutations in the immunoglobulin (Ig) variable heavy chain (V-H ) genes in subsets of MCL. To clarify this issue, we analyzed the IgV(H) genes for the presence of somatic hypermutations in 51 MCL cases. Twenty percent of the MCL cases displayed somatically mutated V-H genes (defined as >2% mutated), whereas 80% showed unmutated V-H genes. This finding suggests that MCL is a genetically heterogeneous disease, with the majority of cases originating from unmutated pre-GC B-cells and a subset deriving from more mature B-cells which have been exposed to the GC environment and have undergone somatic hypermutation. A biased V-H gene usage has been demonstrated in several B-cell malignancies; however, this has not yet been investigated in MCL, although V-H 4-34 overusage has been indicated by small studies. Interestingly, we found a restricted usage of three individual V-H genes in our MCL material; V-H 4-34 (22%), V-H 3-21 (16%) and V-H 5-51 (12%). This novel finding of preferential V-H gene usage in half of the MCL cases may suggest an antigen driven process occurring in B-cells expressing specific V-H genes, thus implicating that Ig specificity could be involved in mantle cell lymphoma development.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据