期刊
TRENDS IN CARDIOVASCULAR MEDICINE
卷 12, 期 3, 页码 101-108出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/S1050-1738(01)00157-8
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The binding of plasma protein fibrinogen (Fg) to intercellular adhesion molecule-1 (ICAM-1) on endothelial cells mediates the attachment of leukocytes and platelets that may result in vascular occlusion. Fg:ICAM-1 interactions elicit an array of effects that could have implications in vascular pathology and inflammation. ICAM-1 expression is regulated during inflammation and upon Fg binding. The mechanistic model presented provides a framework to delineate the consequences of Fg binding to ICAM-1. (C) 2002, Elsevier Science Inc.
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