Adenosine A1 receptor antagonists in the kidney:: effects in fluid-retaining disorders

Adenosine A, receptor antagonists have been used effectively as potassium-sparing and renal-function-protective diuretics in new studies. In addition, the role of adenosine - acting through adenosine A, receptors - in renal autoregulation has been clarified. Finally, the application of adenosine receptor antagonists has been implicated in protection from acute renal failure associated with radiocontrast media treatment.