期刊
MULTIPLE SCLEROSIS
卷 8, 期 2, 页码 93-97出版社
ARNOLD, HODDER HEADLINE PLC
DOI: 10.1191/1352458502ms785rr
关键词
axons; demyelination; inflammation; multiple sclerosis; primary progressive
The present review will focus on the current knowledge of the pathology of primary progressive multiple sclerosis lesions. Multiple sclerosis (MS) is an inflammatory demyelinating disease with a broad clinical variability. The main disease courses are refapsing remitting, secondary progressive and primary progressive MS. Pathological studies examining the specific underlying pathology of a defined clinical subtype are rare. Here, we focus on the phatological characteristics of the MS lesions and summarize the current findings of the phatology of primary progressive MS with respect to inflammation, oligodendrocytelmyelin pathology, axon destruction and immunopothology of the lesions.
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