期刊
JOURNAL OF APPLIED POLYMER SCIENCE
卷 84, 期 1, 页码 44-49出版社
JOHN WILEY & SONS INC
DOI: 10.1002/app.10185
关键词
chitosan membranes; isoniazid; amitriptyline hydrochloride; permeability membranes; drug delivery systems; UV-vis spectroscopy
The permeabilities of isoniazid and amitriptyline hydrochloride in chitosan membranes were investigated. Drug concentration was changed from 0.1 to 1.0% while membrane thickness was varied from 40 to 150 mum. The release rate was measured in water at 30 +/- 0.1degreesC by spectrophotometric determination. The drugs presented quite different permeabilities, which were related to their molecular weights; the permeabilities did not change with thickness or drug concentration for the ranges investigated. (C) 2002 John Wiley Sons, Inc.
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