期刊
JOURNAL OF CHROMATOGRAPHY A
卷 952, 期 1-2, 页码 139-147出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0021-9673(02)00088-2
关键词
tandem mass spectrometry; electrospray ionization; acidic drugs
A liquid chromatography-electrospray ionization tandem mass spectrometry (LC-ESI-MS-MS) method was developed and validated for simultaneous analysis of nine acidic pharmaceutical drugs (bezafibrate. clofibric acid, diclofenac, fenoprofen, gemfibrozil, ibuprofen, indomethacin, ketoprofen and naproxen) in sewage treatment plant (STP) effluents. The mean recoveries of the pharmaceuticals ranged front 58.9 to 91.5% in STP effluent. and the limits of detection of the analytes were 5-20 ng/ml. The method was applied to the quantitative analysis of acidic drugs in the effluents from three Canadian STPs, in which bezafibrate, diclofenac. fenoprofen, gemfibrozil, ibuprofen. indomethacin and naproxen were detected. (C) 2002 Published by Elsevier Science B.V.
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