期刊
TETRAHEDRON LETTERS
卷 43, 期 15, 页码 2725-2729出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0040-4039(02)00403-3
关键词
fostriecin; asymmetric dihydroxylation; coupling reactions; regioselection
In order to synthesize the major C(3)-C(12) part of fostriecin, asymmetric dihydroxylation of several dienes 5a-f, prepared by cross-coupling reactions of several types. vas studied, thus providing high dependency on the hydroxyl groups at C(5) and C(l 1). The best regioselectivity was obtained with 5d to produce diol 23. which was later transformed into the advanced intermediate 26. (C) 2002 Elsevier Science Ltd. All rights reserved.
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