期刊
INTERNATIONAL JOURNAL OF CANCER
卷 98, 期 5, 页码 748-753出版社
WILEY
DOI: 10.1002/ijc.10260
关键词
phage display vaccine; CTL; immunotherapy; tumor-specific antigens; anti-tumor immunity
类别
The efficacy of phage display particles expressing tumor antigen PIA35-43 in inducing protective and therapeutic anti-tumor immune responses were studied. A protective immune response against a lethal progressive P815 mastocytoma tumor cell challenge was established after subcutaneous injection of phage display particles. Furthermore, the vaccine suppressed growth of pre-existing tumors. Immunization with the hybrid phage particles elicited PIA(35-43) specific CTL responses and a Th1-dominated immune response with phage particle-specific secretion of IFN-gamma but not IL-4. Our results indicate that phage display particles might be a useful vaccine form for tumor-associated antigen epitopes in tumor immunotherapy. (C) 2002 Wiley-Liss, Inc.
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