期刊
JOURNAL OF NEUROSCIENCE
卷 22, 期 8, 页码 3005-3015出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.22-08-03005.2002
关键词
AMPA receptors; GluR2 subunit; Ca2+ permeability; pyramidal neurons; neocortex; developmental switch
AMPA receptors mediate most of the fast excitatory neurotransmission in the brain, and those lacking the glutamate receptor 2 (GluR2) subunit are Ca2+-permeable and expressed in cortical structures primarily by inhibitory interneurons. Here we report that synaptic AMPA receptors of excitatory layer 5 pyramidal neurons in the rat neocortex are deficient in GluR2 in early development, approximately before postnatal day 16, as evidenced by their inwardly rectifying current-voltage relationship, blockade of AMPA receptor-mediated EPSCs by external and internal polyamines, permeability to Ca2+, and GluR2 immunoreactivity. Overall, these results indicate that neocortical pyramidal neurons undergo a developmental switch in the Ca2+ permeability of their AMPA receptors through an alteration of their subunit composition. This has important implications for plasticity and neurotoxicity.
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