The synthesis and chemistry of 3-diazo-piperidin-2-one

The efficient synthesis of 3-diazo-piperidin-2-one, from L-ornithine, in two steps is reported. The chemistry of this new cyclic alpha-diazoamide was explored and allows the rapid access to a wide range of 3-substituted piperidin-2-one derivatives. (C) 2002 Elsevier Science Ltd. All rights reserved.