期刊
TETRAHEDRON
卷 58, 期 17, 页码 3329-3347出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0040-4020(02)00286-7
关键词
carbonates; carbamates; cesium; carbonate
Novel solution and solid-phase methods for the synthesis of carbonates and carbamates were developed using cesium bases and TBAT via a three-component coupling. Cesium carbonate not only promoted successful carbonylations of alcohols and carbamations of amines, but also suppressed common side reactions traditionally seen using existing protocols. Various alcohols and amines were examined, using a wide array of alkyl halides. and the results demonstrated this methodology was highly chemoselective. In particular, use of either sterically demanding substrates or amino acid derivatives afforded the corresponding products exclusively, offering a wide variety of applications such as novel protecting groups and peptidomimetic syntheses. (C) 2002 Elsevier Science Ltd. All rights reserved.
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