Anthranilate sulfonamide hydroxamate TACE inhibitors.: Part 1:: Structure-based design of novel acetylenic P1′ groups

The structure-based design of potent sulfonamide hydroxamate TACE inhibitors bearing novel acetylenic P1' groups has led to compounds with excellent in vitro potency against TACE and selectivity over MMP-1. (C) 2002 Elsevier Science Ltd. All rights reserved.