期刊
FEBS LETTERS
卷 517, 期 1-3, 页码 144-150出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0014-5793(02)02608-X
关键词
metacaspase; cysteine protease; WW domain; mitochondrion; Saccharomyces cerevisiae; Trypanosoma brucei
Metacaspases constitute a new group of cysteine proteases homologous to caspases. Heterologous expression of Trypanosoma brucei metacaspase TbMCA4 in the budding yeast Saccharomyces cerevisiae resulted in growth inhibition, mitochondrial dysfunction and clonal death. The metacaspase orthologue of yeast, ScMCA1 (YOR197w), exhibited genetic interaction with WWM1 (YFL010c), which encodes a small WW domain protein. WWM1 overexpression resulted in growth arrest and clonal death, which was suppressed by concomitant overexpression of ScMCA1. GFP-fusion reporters of WWM1, ScMCA1 and TbMCA4 localized to the nucleus. Taken together, we suggest that metacaspases may play a role in nuclear function controlling cellular proliferation coupled to mitochondrial biogenesis. (C) 2002 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.
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