期刊
CELL DEATH AND DIFFERENTIATION
卷 9, 期 5, 页码 493-504出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.cdd.4400987
关键词
Rho; Rac; ROCK; actin cytoskeleton; myosin light chain; phagocytosis; blebbing
The killing and removal of superfluous cells is an important step during embryonic development, tissue homeostasis, wound repair and the resolution of inflammation. A specific sequence of biochemical events leads to a form of cell death termed apoptosis, and ultimately to the disassembly of the dead cell for phagocytosis. Dynamic rearrangements of the actin cytoskeleton are central to the morphological changes observed both in apoptosis and phagocytosis. Recent research has highlighted the importance of Rho GTPase signalling pathways to these changes in cellular architecture, In this review, we will discuss how these signal transduction pathways affect the structure of the actin cytoskeleton and allow for the efficient clearance of apoptotic cells.
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