期刊
NATURE REVIEWS MOLECULAR CELL BIOLOGY
卷 3, 期 5, 页码 317-327出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm805
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The Mre11 complex is a multisubunit nuclease that is composed of Mre11, Rad50 and Nbs1/Xrs2. Mutations in the genes that encode components of this complex result in DNA-damage sensitivity, genomic instability, telomere shortening and aberrant meiosis. The molecular defect that underlies these phenotypes has long been thought to be related to a DNA repair deficiency. However, recent studies have uncovered functions for the Mre11 complex in checkpoint signalling and DNA replication.
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