期刊
MECHANISMS OF DEVELOPMENT
卷 113, 期 2, 页码 111-120出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0925-4773(02)00015-1
关键词
transforming growth factor beta; programmed cell death; apoptosis; interdigital webs; limb; digit formation; development; knockout mice
During limb formation massive cell death in the mesenchyme of the interdigital spaces accompanies the formation of free digits. Members of the transforming growth factor beta (TGF-beta) superfamily were discussed to play a key role in cell-cell interactions, important in the lregulation of programmed cell death (PCD). TGF-beta itself is believed to be involved in epithelial-mesenchymal interactions. Here, we demonstrate that PCD is significantly reduced in interdigital spaces of the developing limbs of Tgfbeta2(-/-)Tgfbeta3(-/-) double knockouts. The regression of interdigital webs seems to be doses-dependent as interdigital mesenchyme is at least partly reduced in Tgfbeta2(-/-)Tgfbeta3(+/-) mutants, whereas interdigital zones of Tgfbeta2(-/-)Tgfbeta3(-/-) double knockouts reveal only minimal signs of regression. We conclude that TGF-beta is a critical extrinsic regulator of PCD. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
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