期刊
MICROBIOLOGY-SGM
卷 148, 期 -, 页码 1475-1481出版社
SOC GENERAL MICROBIOLOGY
DOI: 10.1099/00221287-148-5-1475
关键词
LuxS; autoinducer-2; camplylobacters
类别
The expression of a wide variety of physiological functions in many bacterial species is modulated by quorum sensing, a population-dependent signalling mechanism that involves the production and detection of extracellular signalling molecules. The genome sequence of Campylobacter jejuni NCTC 11168 contains a gene encoding an orthologue of LuxS, which is required for autoinducer-2 (Al-2) production in other bacterial species, but does not contain genes predicted to encode any known acyl-homoserine lactone synthetase. This study demonstrates that C. jejuni produces functional Al-2 activity through the ability of cell-free extracts to specifically induce bioluminescence in Vibrio harveyi 113113170, a reporter strain for quorum-sensing system 2. Production of this signalling compound was shown to be dependent upon the product of the C. jejuni luxS gene (Cj1198). While the luxS mutant showed comparable growth rate, resistance to oxidative stress and ability to invade Caco-2 cell monolayers to the parental strain, it exhibited decreased motility haloes in semisolid media, suggesting a role for quorum sensing in the regulation of motility.
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