期刊
TRENDS IN BIOCHEMICAL SCIENCES
卷 27, 期 5, 页码 222-224出版社
CELL PRESS
DOI: 10.1016/S0968-0004(02)02091-1
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The Mononegavirales virus group comprises several major human pathogens, including measles, rabies and Ebola viruses. This article reports a computational analysis of the C-terminal region of RNA-dependent RNA-polymerases from Mononegavirales. Using a combination of sequence similarity and threading analysis, a 2'-O-ribose methyltransferase domain was identified that is involved in the capping of viral mRNAs.
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