期刊
RADIOLOGY
卷 223, 期 2, 页码 432-438出版社
RADIOLOGICAL SOC NORTH AMERICA
DOI: 10.1148/radiol.2232010241
关键词
contrast media, comparative studies; contrast media, experimental studies; gadolinium; magnetic resonance (MR), contrast media; magnetic resonance (MR), vascular studies
PURPOSE: To investigate intravascular enhancement of bolus-injectable small and ultrasmall superparamagnetic iron oxides (USP10s) of different particle sizes and relaxivities for first-pass and blood-pool magnetic resonance (MR) angiography. MATERIALS AND METHODS: Iron oxides with different particle sizes (hydrodynamic diameters, 21, 33, 46, and 65 nm) were bolus injected intravenously at three doses (10, 20, and 40 mumol per kilogram body weight). An extracellular contrast agent (gadopentetate dimeglumine) served as a control. MR angiography was performed multiple times after intravenous injection (5-120 minutes and 24 hours later). Signal enhancement was calculated from signal intensity measurements in the abdominal aorta and renal and iliac arteries. RESULTS: Highest enhancement was seen during the first pass with all contrast agents. USPIO enhancement in the abdominal aorta increased significantly with decreasing particle size (65 nm vs 33 nm, 65 nm vs 21 nm; P < .01). CONCLUSION: The smallest iron oxide provided signal enhancement comparable with that of gadopentetate dimeglumine at 40 mumol iron per kilogram for first-pass investigations, with prolonged signal enhancement up to 25 minutes, allowing multiple measurements after injection of a single bolus. (C) RSNA, 2002.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据