期刊
CURRENT OPINION IN HEMATOLOGY
卷 9, 期 3, 页码 190-198出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00062752-200205000-00003
关键词
-
类别
Peripheral blood stem cells (PBSC) have become the preferred source of stem cells for autologous transplantation because of the technical advantage and the shorter time to engraftment. Mobilization of CD34(+) into the peripheral blood can be achieved by the administration of granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage colony-stimulating factor (GM-CSF), or both, either alone or in combination with chemotherapy. G-CSF and GM-CSF differ somewhat in the number and composition of PBSCs and effector cells mobilized to the peripheral blood. The purpose of this review is to give a recent update on the type and immunologic properties of CD34(+) cells and CD34(+) cell subsets mobilized by G-CSF or GM-CSF with emphasis on (1) relative efficacy of CD34(+) cell mobilization; (2) relative toxicities of G-CSF and GM-CSF as mobilizing agents; (3) mobilization of dendritic cells and their subsets; (4) delineation of the role of adhesion molecules, CXC receptor 4, and stromal cell-derived factor-1 signaling pathway in the release of CD34(+) cell to the peripheral blood after treatment with G-CSF or GM-CSF. Curr Opin Hematol 2002, 9:190-198 (C) 2002 Lippincott Williams Wilkins, Inc.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据