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Mechanisms of inhibition of the host interferon α/β-mediated antiviral responses by viruses

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MICROBES AND INFECTION
卷 4, 期 6, 页码 647-655

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ELSEVIER SCIENCE BV
DOI: 10.1016/S1286-4579(02)01583-6

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interferon; interferon antagonist; innate immunity

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Complex multicellular organisms have evolved sophisticated mechanisms to prevent and control infection by pathogens. Among these mechanisms, the type I interferon or interferon alpha/beta system represents one of the first lines of defense against viral infections. Typically, viral infection induces the synthesis and secretion of interferon alpha/beta by the infected cell, which in turn activates signaling pathways leading to an antiviral state. As a counter measure, many viruses have developed intriguing mechanisms to evade the interferon alpha/beta system of the host. In this review, we will summarize recent research developments in this interesting field of virus-host cell interactions. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.

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