期刊
NATURE REVIEWS IMMUNOLOGY
卷 2, 期 5, 页码 346-353出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nri800
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- Biotechnology and Biological Sciences Research Council [BB/D523578/1, BBS/B/13500, G18647, BBS/E/R/00000690, BB/D013704/1] Funding Source: Medline
Discrimination between self and non-self by lectins (carbohydrate-binding proteins) is a strategy of innate immunity that is found in both vertebrates and invertebrates. In vertebrates, immune recognition mediated by ficolins (lectins that consist of a fibrinogen-like and a collagen-like domain), as well as by mannose-binding lectins, triggers the aeration of the complement system, which results in the activation of novel serine proteases. The presence of a similar lectin-based complement system in ascidians, our closest invertebrate relatives, indicates that the complement system probably ha pivotal role in innate immunity before the evolution of an adaptive immune system in jawed vertebrates.
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