期刊
DIABETES
卷 51, 期 5, 页码 1346-1355出版社
AMER DIABETES ASSOC
DOI: 10.2337/diabetes.51.5.1346
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资金
- NIDDK NIH HHS [R01 DK026190] Funding Source: Medline
Age-dependent associations between type I diabetes risk genes HLA, INS VNTR, and CTLA-4 and antoantibodies to GAD65 (GADAs), ICA512/IA-2, insulin, and Islet cells were determined by logistic regression analysis in 971 incident patients with type 1 diabetes and 702 control subjects aged 0-34 years. GADAs were associated with HLA-DQ2 in young but not in older patients (P = 0.009). Autoantibodies to insulin were negatively associated with age (P < 0.0001) but positively associated with DQ8 (P = 0.03) and with INS VNTR (P = 0.04), supporting possible immune tolerance induction. ICA512/IA-2 were negatively associated with age (P < 0.0001) and with DQ2 (P < 0.0001) but positively associated with DQ8 (P = 0.04). Males were more likely than females to be negative for GADA (P < 0.0001), autoantibodies to islet cells (P = 0.04), and all four autoantibody markers (P = 0.004). The CTLA-4 3' end microsatellite marker was not associated with any of the autoantibodies. We conclude that age and genetic factors such as HLA-DQ and INS VNTR need to be combined with islet autoantibody markers when evaluating the risk for type 1 diabetes development.
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