期刊
JOURNAL OF BACTERIOLOGY
卷 184, 期 9, 页码 2552-2556出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JB.184.9.2552-2556.2002
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资金
- NIGMS NIH HHS [GM-57059, R01 GM057059] Funding Source: Medline
The septal ring in Escherichia coli consists of at least nine essential gene products whose order of assembly resembles a mostly linear dependency pathway: FtsA and ZipA directly bind FtsZ polymers at the prospective division site, followed by the sequential addition of FtsK, FtsQ, FtsL, FtsW, FtsI, and FtsN. Recruitment of FtsK and all downstream components requires the prior localization of FtsA. Here we show that recruitment of FtsK, FtsQ, FtsL, and FtsN equally requires ZipA. The results imply that association of both FtsA and ZipA with FtsZ polymers is needed for further maturation of the nascent organelle.
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