期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 124, 期 17, 页码 4716-4721出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja0126226
关键词
-
A concise, stereocontrolled, and practical synthesis of a neuraminidase inhibitor consisting of a highly functionalized D-proline scaffold is described. Key features involve a stereocontrolled addition of a propiolate ester to a chiral nonracemic nitrone derived originally from D-serine and the manipulation of acyclic and cyclic motifs en route to the target in 12.8% overall yield over 22 steps, Several crystalline intermediates were suitable for single-crystal X-ray analysis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据