期刊
JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN
卷 16, 期 5-6, 页码 415-430出版社
SPRINGER
DOI: 10.1023/A:1020863921840
关键词
combinatorial chemistry; cyclic peptide; diketopiperazine; library synthesis; piperazine-2,5-dione; privileged structure; ring contraction; solid-phase
Head-to-tail cyclic peptides have been reported to bind to multiple, unrelated classes of receptor with high affinity. They may therefore be considered to be privileged structures. This review outlines the strategies by which both macrocyclic cyclic peptides and cyclic dipeptides or diketopiperazines have been synthesised in combinatorial libraries. It also briefly outlines some of the biological applications of these molecules, thereby justifying their inclusion as privileged structures.
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