期刊
CLINICAL IMMUNOLOGY
卷 103, 期 2, 页码 125-131出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1006/clim.2001.5167
关键词
EAE; MS; CCR2; MCP-1; monocyte; chemotaxis; treatment
类别
Monocytes and macrophages play a pathogenic role in a number of autoimmune inflammatory diseases. Recent studies in experimental autoimmune encephalomyelitis (EAE), the animal model of multiple sclerosis, have identified a critical chemokine-mediated mechanism of monocyte homing to the central nervous system (CNS). Here, we summarize the current findings in EAE, develop a rationale for targeting the chemokine axis in order to treat CNS inflammatory disease, and review currently available molecule-specific therapeutics that inhibit monocyte trafficking to the CNS. (C) 2002 Elsevier Science (USA).
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