期刊
MICROBES AND INFECTION
卷 4, 期 6, 页码 635-646出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S1286-4579(02)01582-4
关键词
tuberculosis; Mycobacterium tuberculosis; human immunodeficiency virus type 1; granuloma; cell-mediated immunity
The granuloma plays a critical role in the host immune response to Mycobacterium tuberculosis, containing the organism and confining it in a latent state in most infected individuals. Indeed, approximately one-third of the world's population has latent M. tuberculosis infection. However, over the past decade, the human immunodeficiency virus type I (HIV-1) pandemic has profoundly affected the incidence and clinicopathological features of tuberculosis. This review examines the immunological mechanisms whereby HIV-1 impairs the establishment, maintenance and function of the tuberculous granuloma. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
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