期刊
JOURNAL OF PHARMACEUTICAL SCIENCES
卷 91, 期 5, 页码 1274-1286出版社
ELSEVIER SCIENCE INC
DOI: 10.1002/jps.10141
关键词
alprazolam; photochemical degradation; alprazolam stability; triazolo-benzodiazepines; alprazolam photodegradation products
Accelerated thermal, hydrolytic, and photochemical degradations of alprazolam were performed under several reaction conditions. The stress studies revealed the photolability of the drug as the most adverse stability factor; the main photodegradation products were isolated and properly characterized as: triazolaminoquinoleine; 5-chloro[5-methyl-4H-1,2,4-triazol-4-yl]benzophenone, and 1-methyl-6-phenyl-4H-s-triazo[4,3-alpha][1,4]benzodiazepinone. Accelerated pH-dependent studies show that the photoinstability increases as the pH decreases; at pH 9.0, photodegradation does not occur, therefore, the photochemical degradation of alprazolam was performed in buffered solutions at pH 2.0 and 3.6. The higher rate of reaction was observed at pH=2.0; consequently, acidic conditions should be avoided and appropriate light protection is recommended during the drug-development process, storage, and handling. The main degradation route for alprazolam tablets is also photochemical. (C) 2002 Wiley-Liss, Inc. and the American Pharmaceutical Association.
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