期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 46, 期 5, 页码 1535-1539出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.46.5.1535-1539.2002
关键词
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资金
- NIAID NIH HHS [R01-AI43917] Funding Source: Medline
In some enterobacterial pathogens, but not in Escherichia coli, loss-of-function mutations in the ampD gene are a common route to beta-lactam antibiotic resistance. We constructed an assay system for studying mechanism(s) of enterobacterial ampD mutation using the well-developed genetics of E. coli. We integrated the Enterobacter ampRC genes into the E. coli chromosome. These cells acquire spontaneous recombination- and SOS response-independent beta-lactam resistance mutations in ampD. This chromosomal system is useful for studying mutation mechanisms that promote antibiotic resistance.
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