期刊
PHARMACOLOGY
卷 65, 期 1, 页码 2-9出版社
KARGER
DOI: 10.1159/000056179
关键词
ursodeoxycholate; deoxycholate; promoter activation; response element activation; metallothionein
资金
- NCI NIH HHS [CA23074] Funding Source: Medline
- NIEHS NIH HHS [ES06694] Funding Source: Medline
Ursodeoxycholate, used to treat a variety of pathologies, has the ability to reverse cytotoxic and hepatotoxic conditions. We examined HepG2, a hepatic cell line, treated with increasing levels of ursodeoxycholate, for responses of a range of promoters/response elements responsive to DNA damage, heavy metal ions, protein denaturants, aromatic hydrocarbons, retinoids, changes in intracellular AMP levels, end endoplasmic reticulum stress. The metallothionein IIA promoter was the most highly activated by ursocleoxycholate. Since ursocleoxycholate protects against the cytotoxic effects of deoxycholate, our data, combined with observations made by others, implicate metallothionein IIA as being important in this protective pathway. Copyright(C)2002 S. Karger AG, Basel.
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