期刊
FREE RADICAL BIOLOGY AND MEDICINE
卷 32, 期 9, 页码 797-803出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0891-5849(02)00780-3
关键词
3-nitrotyrosine; carbonyls; dityrosine; Alzheimer's; Parkinson's; Huntington's; amyotrophic lateral sclerosis; free radical
There is a large body of evidence implicating oxidative damage in the pathogenesis of both normal aging and neurodegenerative diseases. Oxidative damage to proteins has been well established. Although there are a large number of potential oxidative modifications only a few have been systematically studied. The most frequently studied marker of oxidative damage to proteins is protein carbonyl groups. 3-Nitrotyrosine is thought to be a relatively specific marker of oxidative damage mediated by peroxyrritrite. Increased concentrations of both protein carbonyls and 3-nitrotyrosine have been documented in both normal aging as well as in Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS). These findings help to provide a rationale for trials of antioxidants in neurodegenerative diseases. (C) 2002 Elsevier Science Inc.
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