期刊
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
卷 57, 期 5, 页码 B198-B201出版社
GERONTOLOGICAL SOCIETY AMER
DOI: 10.1093/gerona/57.5.B198
关键词
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资金
- Intramural NIH HHS [Z01 AG000924, Z01 AG000723] Funding Source: Medline
- NIA NIH HHS [T32 AG000114, K01 AG000723, K01 AG000701-04, T32 AG00114, K24 AG000924] Funding Source: Medline
The purpose of this study was to determine if age-related muscle atrophy is associated with an increased rate of protein degradation in extensor digitorum longus (EDL) muscles from young (YG, 2-4 months), middle-aged (MA, 12-17 months), and aged (AG; 22-24 months) B6C3F1 mice. EDL muscles from AG mice weighed less than EDL muscles from MA mice (p = .01). EDL muscles from MA mice weighed more than EDL muscles from YG mice (p = .02). The rate of protein degradation, as assessed by tyrosine release during in vitro incubations, was higher in EDL muscles from AG mice than it was in those from MA mice (p = .03). The rate of protein degradation was higher in EDL muscles from YG mice than it was in those from MA mice (p = .04). An inverse relationship existed between Muscle mass and protein degradation (r = -.67; p = .0001). We conclude that skeletal muscle protein degradation rates decrease with maturation and increase with advancing age.
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