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Genealogical trees, coalescent theory and the analysis of genetic polymorphisms

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NATURE REVIEWS GENETICS
卷 3, 期 5, 页码 380-390

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NATURE PUBLISHING GROUP
DOI: 10.1038/nrg795

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Improvements in genotyping technologies have led to the increased use of genetic polymorphism for inference about population phenomena, such as migration and selection. Such inference presents a challenge, because polymorphism data reflect a unique, complex, non-repeatable evolutionary history. Traditional analysis methods do not take this into account. A stochastic process known as the 'coalescent' presents a coherent statistical framework for analysis of genetic polymorphisms.

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