期刊
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
卷 43, 期 1, 页码 13-17出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/S0732-8893(02)00361-9
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The activities of the echinocandins caspofungin and anidulafungin were evaluated alone and in combination With fluconazole using time-kill methods against isolates of Candida albicans, Candida glabrata, Candida tropicalis, Candida krusei, and Cryptococcus neoformans. Antifungal concentrations tested against each isolate were 0.5 mug/mL and 20 mug/mL of fluconazole and 0.007 mug/mL and 2 mug/mL of both caspofungin and anidulafungin. In addition, 20 mug/mL of fluconazole was tested with 2 mug/mL of caspofungin and anidulafungin to test for additive or antagonistic activity. Finally 0.5 mug/mL of fluconazole was tested with 0.007 mug/mL of caspofungin and anidulafungin to test for synergy. Combinations of fluconazole and caspofungin or anidulafungin resulted in indifference. Azoleechinocandin combinations do not produce antagonistic effects; therefore, combinations of these agents may warrant future clinical evaluation. (C) 2002 Elsevier Science Inc. All rights reserved.
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