期刊
INFECTION GENETICS AND EVOLUTION
卷 1, 期 3, 页码 191-199出版社
ELSEVIER
DOI: 10.1016/S1567-1348(02)00026-6
关键词
Calomys; Machupo; Bolivian hemorrhagic fever; Systematics; Infection; Bolivia; Beni; Arenaviridae
资金
- NIH [AI39780-04]
- National Science Foundation (NSF) [BSR 9015454, BSR 89200617, INT 9212839, BSR-8906665]
- National Geographic Society [4820-92]
Zoonoses within wild reservoir host populations often occur focally obeying Pavlovskii's rules of natural nidality. What appears to be a clear example is Bolivian hemorrhagic fever (BHF), a disease endemic to northeastern Bolivia. The etiological agent is Machupo virus (MACV, Arenaviridae). The vertebrate reservoir, identified 30 years ago, was Calomys callosus a wild rodent common to open biomes in the lowlands of southeastern South America. The lack of concordance between the occurrence of MACV and the range of its rodent host has puzzled cadres of researchers and could be used as an exemplar of natural nidality. Here, we show that the populations of rodents responsible for the maintenance and transmission of MACV are an independent monophyletic lineage, different from those in other areas of South America. Therefore a clearer understanding of the systematics of the host species explains the apparent natural nidality of BHF. Similar studies may prove to be informative in other zoonoses. (C) 2002 Elsevier Science B.V. All rights reserved.
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