期刊
CELL CYCLE
卷 1, 期 3, 页码 162-168出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.1.3.118
关键词
Checkpoint; Tumor suppressor; CDK inhibitor; Genetic instability
类别
资金
- Deutsche Forschungsgemeinschaft
- Boehringer Ingelheim Fond
- ELAN-Program of the University of Erlangen-Nuremberg
Cell cycle checkpoints constitute a network of signal transduction mechanisms to monitor DNA damage and replication and thereby regulate progression through the cell cycle. A series of events is triggered in cells upon DNA damage. Here we describe a framework for the understanding of the functions of the core components involved in the cell cycle response to DNA damage and the relevance to the origin of cancer.
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