期刊
JOURNAL OF VIROLOGY
卷 76, 期 10, 页码 4886-4890出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.76.10.4886-4890.2002
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资金
- NCI NIH HHS [CA-21765, P30 CA021765] Funding Source: Medline
- NIAID NIH HHS [AI95357, AI29860] Funding Source: Medline
- Wellcome Trust Funding Source: Medline
A/Goose/Guangdong/1/96-like H5N1 influenza viruses now circulating in southeastern China differ genetically from the H5N1 viruses transmitted to humans in 1997 but were their precursors. Here we show that the currently circulating H9N2 influenza viruses pro-vide chickens with cross-reactive protective immunity against the currently circulating H5N1 influenza viruses and that this protective immunity is closely related to the percentage of pulmonary CD8(+) T cells expressing gamma interferon (IFN-gamma). In vivo depletion of T-cell subsets showed that the cross-reactive immunity was mediated by T cells bearing CD8(+) and T-cell receptor (TCR) alpha/beta and that the Vbeta1 subset of TCR alpha/beta T cells had a dominant role in protective immunity. The protective immunity induced by infection with H9N2 virus declined with time, lasting as long as 100 days after immunization. Shedding of A/Goose/Guangdong/1/96-like H5N1 virus by immunized chickens also increased with the passage of time and thus may play a role in the perpetuation and spread of these highly pathogenic H5N1 influenza viruses. Our findings indicate that pulmonary cellular immunity may be very important in protecting naive natural hosts against lethal influenza viruses.
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