期刊
INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY
卷 44, 期 2, 页码 101-115出版社
ELSEVIER
DOI: 10.1016/S0167-8760(01)00196-9
关键词
schizophrenia; asymmetry; connectivity; binding phenomenon
During the last decade the role of high frequency EEG activity in the 'binding phenomenon' was discovered. It was supposed that this phenomenon provided the integration between different brain structures underlying higher nervous functions and possibly even consciousness [Proc. Natl. Acad. Sci. 90 (1993) 2078; Annu. Rev. Neurosci. 18 (1995) 555; J. Neurosci. V 16 (1996) 4240; Am. Physiol. Soc. (1998) 1567; Induced Rhythms in the Brain (1992) 425; NeuroReport 8 (1997) 531; Proc. Natl. Acad. Sci. USA 94 (1997) 12198]. Schizophrenia is considered as a disorder of the integration between different brain regions [Review of Psychiatry 18 (1999a) 29; Conceptual Advances in Russian Neuroscience: Complex Brain Functions (1999) 151; Brain Res. Rev. 31 (2000) 301], and in the present work we have studied cortical connectivity, focusing on those connections which are maintained by high frequency EEG-rhythm (20-40 Hz). The results showed a high degree of biopotential synchronisation between definite cortical areas during cognitive processes in normal subjects and have evidenced significant functional connectivity disturbances in schizophrenia in this EEG frequency domain. (C) 2002 Elsevier Science B.V. All rights reserved.
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