期刊
ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY AND ITS RELATED SPECIALTIES
卷 64, 期 3, 页码 200-205出版社
KARGER
DOI: 10.1159/000058025
关键词
oral cancer; Ki-67; prognosis; archival material; formamide; histological grading
Prognostic relevance of Ki-67 staining in oral squamous cell carcinomas was investigated by immunohistochemical expression in 329 cases of squamous cell carcinoma of the oral cavity due to a formamide pretreatment. The growth fraction (Ki-67 labelling index, LI) was correlated to histopathological grading, lymphocytic reaction, stroma/tumour proportion, pattern of invasion, mitotic rate, degree of keratinisation, tumour size, thickness of tumor, depth of invasion, lymph node involvement and five-year survival rate. Highly significant inverse correlation was found between the Ki-67 Ll, the stroma/tumour proportion and the degree of keratinisation whereas no correlation could be established between the Ki-67 Ll and all the other histological and clinical paramters. Ki-67 staining alone has no prognostic relevance in oral cancer. Copyright (C) 2002 S. Karger AG, Basel.
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